PSL300H1 Study Guide - Final Guide: Ion Channel, Muscarinic Acetylcholine Receptor, Second Messenger System
7 Jan 2017
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Lecture outline: how to generate an ap at the post-synaptic neuron at the chemical synapse. Transmitter agent diffuses across synapse and binds to a specific site on a receptor protein embedded in postsynaptic membrane. Binding of transmitter causes a change in shape of the receptor protein. Ionotropic: directly opens channels: metabotropic: initiates a metabolistic cascade the activate enzymes. Receptor determines the effect, not the transmitter. Ligand binding opens an ion channel ionotropic. Post-synaptic potential (psp): change in the post- synaptic membrane potential due to binding of the transmitter to the post-synaptic membrane. Duration of psp is about 20-40ms (as long as the transmitters are present) Ion channel may be specific for cations (na+, k+) epsp (depolarizing. Binding of nt will result in one or two things to happen; the effect on the post-synaptic neuron will be dependent on the type of receptors the nts will bind to. The receptor determines the effect, not the nts.
