NTDT401 Lecture 2: Thiamin B1
21 Sep 2016
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Thiazole ring (s-containing, reactive c, p/phosphorylation part) Thiamin can only be absorbed in free form (without p) because it has a charge --> will not penetrate lipid bilayer. Donates 2 p, causing atp --> amp and those p go to tdp/tpp. Made of vitamins and aid enzymatic reactions. Allows substrates/reactants into enzymatic reactions for the reaction to happen. Modified vitamin form to help enzymes in reactions. Without coenzymes, compounds don"t respond to their enzymes. Remove the p to remove charges --> free form allow easier penetration of membrane. Passive transport --> diffusion; active is <5 mg/d. Ethanol - inhibits transport of thiamin from the mucosal cell across basolateral membrane. Tmp (1p) - is free or bound to albumin & most in rbcs. 30 mg of thiamin found in human body. Functions: energy release/transformation - pdh & akg dehydrogenase complexes, decarboxylations, synthesis of nadph and pentoses. Reaction of pyruvate dehydrogenase enzyme (what goes in / what comes out)
