ANFS332 Lecture Notes - Lecture 18: Herpes Simplex Keratitis, Respiratory Tract, Neurological Disorder
27 Nov 2016
School
Department
Course
Professor
Document Summary
Herpesvirus properties: enveloped virions (~150 nm in diameter) Icosahedral capsid (162 capsomers: linear dsdna genome (120-240 kb, replicates in the nucleus, produces intranuclear inclusion bodies, envelope is acquired by budding through the nuclear membrane, establishes latent infections with recurrent or continuous shedding of infectious virus. Inclusion bodies: abnormal structures which appear within the cell nucleus, the cytoplasm, or both, during the course of virus multiplication. In some virus infections, inclusion bodies may be simply masses of maturing virus particles. In other infections inclusions may be remnants of the process of virus multiplication: negri body cytoplasm of rabies-infected cells. Grow rapidly, establish latent infections in sensory nerve ganglia, some have a broad host range. Restrictive host range, grows slowly, may establish latency in tissues such as salivary glands and kidneys. Narrow host range, replicate in lymphoid cells where they can establish latency.
