MICR 221 Lecture Notes - Lecture 29: Phosphodiester Bond, Vaccinia, Herpes Simplex Virus Protein Vmw65
24 Apr 2018
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Document Summary
Lifelong infection, resurfaces under stressful conditions- turtles get tumors due to stress from climate change, chemicals ect. All are spherical enveloped virions, 120-200 nm in d. Icosahedral capsid w 162 capsomeres covered by lipid envelope containing diff glycoproteins, some w spikes. Cytocidal, intranuclear inclusions and sometimes cytomegalic cells or syncytia formation. Alpha protein code dna binding proteins that ref virus gene expression + help evade immune sys. B proteins: code for enzymes involved in nucleotide metabolism + dna rep. Gamma: structural proteins prod after virus rep started. Establish latent infections w only some genes expressed during latency. Fragile outside host, transmission requires close contact (sneezes, livestock) 3 subgroups alphaherpesvrinael hsv-1 and vzv grow rapidly and lyse infected cells. Latent infection in neurons of pns (stays here until triggered then travels down axon and infects cells at end) Hsv broad host range, vzv infects humans only. 1 in 5 adults have genital herpes w 80% undiagnosed.
