PNB 2265 Lecture Notes - Lecture 12: Macrophage, Vasodilation, Hydrolysis
13 Mar 2017
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Vasodilation, increased capillary permeability: kinins (bradykinins, etc. ) Chemotaxis, stimulate neutrophils induce pain: prostaglandins (eicosanoids) Sensitive blood vessels to effects of other mediators; pain. Phagocytes mobilized: neutrophils enter bloodstream, margination ( pavementing , diapedesis -> neutrophils cross capillary walls, chemotaxis. Complement system (nonspeci c: major mechanism for destroying foreign substances. 2 pathways for activation: classical (antigen/antibody) and alternative: once activated: Directly lyse target cells via membrane attack complex. Classical pathway: antigen/antibody, initiates complement xation, c1 binds constant (fc) region of antibody. Alternative: polysaccharides on cell surfaces of certain fungi/bacteria, secrete factors b,d. Function of complement system: increase/enhance in ammation, kill bacteria/other cells, mechanism of elimination of tagged antigen. Antimicrobial proteins: interferons: protein family with antiviral effects, host (not virus) speci c, interfere with viral replication, stimulate nk cells, and macrophages. Toll-like receptors: pamps (pathogen-associated molecular proteins, macrophages and dendritic cells have receptors that recognize pamps, many pathogens share features called pamps.
