PNB 2265 Lecture Notes - Lecture 14: Vascular Permeability, Mast Cell, Neutrophil
17 Feb 2017
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Don"t have to have infection to have inflammation. Chemical mediators cause vasodilation and capillary permeability; chemoattractants recruit neutrophils to area. Diapedesis results in neutrophils entering tissue where they engulf bacteria. Capillaries return to normal as neutrophils continue to clear the infection. What are the chemical alarms that mediate inflammation. Vasodilation, capillary permeability, also chemotaxis, stimulate neutrophils, induce pain. Sensitive blood vessels to effects of other mediators; pain. Cytokines - general term for other cell chemicals. Phagocytosis engulf non-specifically combine with lysosome chop up release of end products into or out of cell. Neutrophil is wbc that hunt and kill bacteria. Plasma proteins in blood circulating to produce, non specific response. Many different things initiate response is same. Mechanism for elimination of tagged antigen (result of antibody mediated immune response) Two pathways for activation: classical and alternative. Antigen - antibody complex initiates complement fixation . C1 binds constant (fc) region of antibody. Stem of y shaped antibody (same for each)
