PNB 2265 Lecture Notes - Lecture 15: B Cell, Lymph Node, T Cell

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Defends against free bacteria and viruses in blood/body fluids. Specific antibodies are secreted by b lymphocytes. Mediated by cytotoxic t lymphocytes. (e. g. , cells transformed by cancer; viral infection) Both categories have the following three stages: Processing of antigen (ag) by macrophage, dendritic cell or b cell (processing always in cell-mediated immune response; often in antibody-mediated; we will presume processing occurs in antibody-mediated) For b cells, this step is sometimes called sensitization . Involves lymphocyte differentiating into a clone of identical lymphocytes, which then proliferate. Without this activation step, and the subsequent clonal expansion. May involve tagging antigen (antibody-mediated defense) or actual lysis of targeted cells (cell-mediated) Antibodies don"t kill, they attract things that will. Active: your immune system is awakened by antigen challenge a) involves an active primary immune response to specific antigen. Your immune system responded to antigen by activating formation of a clone of specific b cells that produced antibodies to that antigen.

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