PNB 2265 Lecture Notes - Lecture 16: Immunosuppression, Natural Killer Cell, Rheumatoid Arthritis

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Antigen processing and presentation to helper t cells. Three events are required for the activation of helper t cells. Presentation of ag bound to class ii mhc protein on an apc. Costimulation: the binding of matching nonantigenic proteins in membrane of apc and helper. Defends against free bacteria and viruses in body fluids. Specific b lymphocytes are activated to produce specific antibodies, which (cid:498)tag(cid:499) antigen. Antigen recognition: b cell selection and activation, processed and presented by apc to specific helper t cell. Helper t cytokines required for clonal expansion. Selected b cell differentiates plasma and memory cells. 99% antigens recognized by lymph nodes, sometimes spleen. Epitope: specific antibody attached to the antigen. Proteins don"t just start the response, you need the antigen. Interleukin 1 from t cell: helper t cell produces interleukin 2, positive feedback. Clone formation to make identical cells: helper t cells. Memory: save for later: activate selected b cell, which can now clone.

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