PNB 2265 Lecture Notes - Lecture 16: Bronchodilator, Thoracic Cavity, Pulmonary Pleurae
27 Feb 2017
School
Department
Course
Professor
Document Summary
Retrovirus destroys helper t cells (cd4 cells) Herd immunity because cannot immune everything right when born. Can"t be immunized most people can so protected. Proteins are brakes way for your cell to say not me . Cancer cells learn to express this proteins too. Bind to receptors for not me step. Targets include proteins whose normal function is to modulate normal immune responses, and suppress inappropriate immune responses. Expressed by (mostly) t cells, including cd-4 and cd-8. Sends inhibitory signal to apcs, blocks costimulation. Expressed on several immune cells, especially tc (ctl) is. One ligand (of two) is pd-l1 expressed by certain cell types, including t cells and apcs. Interaction of pd-1 and pd-l1 acts as brake on t cell activation/proliferation. Both play roles in prevention of autoimmune disease and allowing. Pd-1 signaling tolerance of fetus during pregnancy. Example of pd-1 signaling to attenuate response to viral infection (normal. Tumor cells expressing pd-l1 can escape immune response.
