NURS 3110 Lecture Notes - Lecture 18: Genetic Predisposition, Mycobacterium Leprae, Rifampicin
Document Summary
Infection in lungs, sputum, coughing, pain: growing concern internationally, extensively drug-resistant (xdr) tb in the united states, xdr tb is a rare type of mdr tb, resista(cid:374)t to inh, rif, fluo(cid:396)o(cid:395)ui(cid:374)olo(cid:374)es, a(cid:374)d (cid:1005) of (cid:1007) i(cid:374)je(cid:272)ta(cid:271)le (cid:1006)(cid:374)d-line drugs. Infections: via inhalation of droplets of mycobacterium tb (only 10 organisms needed) India (8%: china (6%, guatemala (3%, haiti (3%) Likelihood of tb infection or latent tb: exposure to tb droplets. Inhaled into lungs: no infection in 10-20% of cases, lung macrophages engulf bacilli, infection occurs in 80-90% of cases; tb test + The cells form a barrier shell, called a granuloma, that keeps the bacilli contained and under control (ltbi). If the immune system cannot keep the tubercle bacilli under control, the bacilli begin to multiply rapidly (tb disease). 48 hrs and at 72 hrs: + test indicates prior contact with mycobacterial proteins (incl.
