MCB 2410 Lecture Notes - Lecture 16: Tumor Suppressor Gene, Cancer, Benign Tumor
17 Dec 2018
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Document Summary
Malignant tumor - cells invade other tissues. Metastasis - advanced tumors shed cells that travel to other parts of the body. Early observations that showed cancer was genetic. Come specific cancers run in families (ex. retinoblastoma) Cells do not respond to normal controls of cell division. A model to study cell cycle control. Tumor growth - cells divide rapidly and constantly. Crowds the normal cells and robs nutrients. If one or more mutations are inherited, less mutations would be required to produce cancer. Most tumors arise from somatic mutations that accumulate in a person"s life span. The rate of clonal evolution depends on the frequency with which new mutations arise. Ex: mutation cell predisposed to proliferate faster, causes cell to divide rapidly, undergoes structural changes, causes cell to divide uncontrollably and invade other tissue. Oncogenes - mutated dominant acting stimulatory gene. Have a stimulatory effect on the the cell cycle. Mutation causes hyperactive stimulator factor excessive cell proliferation.
