MCB 2210 Lecture Notes - Lecture 17: Micelle, Transcytosis, Ldl Receptor
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3 Apr 2016
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This is the sorting compartment of the golgi. Controls the flow of vesicles outward toward the plasma membrane. If no added signal, proteins move on to secretory vesicles which fuse with the plasma membrane (constitutive secretion or exocytosis) Puts membrane proteins in the plasma membrane o. If a signal is present the protein is diverted: Some unknown signal must retain certain proteins in the golgi. Lysosomes: cytoplasmic vesicles that take part in degradation of macromolecules o. Internal environment is acidic due to a membrane pump that transports h+ in using atp as an energy source: contents are hydrolytic enzymes (degrade macromolecules) that work in an acid environment (acid hydrolases) only function at a specific ph. Lysosomal component containing vesicles from the golgi fuse with incoming endocytic vesicles to create late endosomes that mature into lysosomes. The degraded material can be transported to the cytoplasm and used for synthesis or dumped out of the cell.