MCB 2210 Lecture Notes - Lecture 16: Phagocytosis, Cisterna, Glycosphingolipid
3 Apr 2016
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Document Summary
Some receptors are recycled during receptor mediated endocytosis: others can be targeted for degradation. Ldl processing by cells receptor mediated endocytosis pathways: low density lipoproteins (ldl) move cholesterol from liver to other body cells. Large protein plus micelle of lipid & cholesterol o o. Internalized by receptor-mediated endocytosis: early endosome is a sorting compartment. The receptor is sorted and sent back to the surface. The ldl is sent on the lysosomes for processing: late endosomes become multi-vesicular to degrade targeted proteins while protecting others. What"s inside the vesicular bodies in the endosomes are degraded. Mono-ubiquitination tag proteins and target them for destruction in the cytoplasm. Escrt complex forms backwards buds in endosome membrane. Subverted for hiv budding: ubiquitinated viral gag protein mimics. Hrs protein triggers formation of escrt complex outward budding of gag polymer shell and thus viral budding o. Individuals with genetic disorders of cholesterol metabolism have defects in the delivery machinery.
