MCB 2210 Lecture Notes - Lecture 15: Profilin, Atp Hydrolysis, Treadmilling
3 Apr 2016
School
Department
Course
Professor
Document Summary
Actin overview: subunit: actin, organization: bundles, networks, smallest of the 4 cytoskeletal polymers, location: cytoplasm, plasma membrane, cell junctions, functions: locomotion, shape change, cytokinesis, adhesion. And - actin in non-muscle cells: (do bacteria have a cytoskeleton?) Actin filaments are helical polymers composed of globular actin monomers that bind atp: monomers= bound to atp, polymers (filaments)= can hydrolyze atp to adp. Structure: actin monomer is separated into 2 lobes by a deep cleft that binds atp or. Adp complexed with mg2: actin exists in two forms in the cell: Helical polymer of g-actin subunits held together by noncovalent (hydrophobic and ionic) interactions. A polar polymer: all of the subunits within an actin filament have the same polarity. Oriented in the same direction: the 2 ends of a filament are different have different dynamic properties. When the monomers form filaments, + ends bind to ends.
