PSYCH 15 Lecture Notes - Lecture 14: Cerebellum, Prefrontal Cortex, Basal Forebrain
Document Summary
Monkeys with bilateral medial temporal lobectomies show deficits in ltm in delayed nonmatching-to-sample test. Like hm, performance was normal when memory needed to be held for a few seconds (within. Aspiration lesions in monkeys caused additional cortical damage. Bilateral damage to hippocampus, amygdala, rhinal cortex same deficits seen in monkeys with hippocampal lesions. Bilateral removal of rhinal cortex object recognition deficits. Bilateral removal of hippocampus no or moderate effects. Bilateral removal of amygdala no effects. Complete lesion of hippocampus moderate deficits in object recognition. Small lesions of hippocampus from ischemias severe deficits in object recognition. Ischemia-induced hyperactivity of ca1 pyramidal cells damages nervous outside hippocampus. Extrahippocampal damage not readily detectable, but is largely responsible for ischemia- induced object recognition deficits. Hippocampectomy deficits on morris water maze, radial arm maze in rats. Many hippocampal cells are place cells--respond when subject is in a particular place and to other cues. Only fires in response to certain region.
