MCD BIO 90 Lecture Notes - Lecture 10: Organoid, Germ Layer, Teratoma
5 Apr 2018
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Document Summary
A collection of organ-specific cell types that develops from stem cells or organ progenitors and self-organizes through cell sporting and spatially restricted lineage commitment in a manner similar to in vivo. Transcription factors decide which organ or path the stem cells will take. The starting stem cell population must be pluripotent because there are multiple germ layers in an organ (eg. In the heart there are cardiac cells and blood cells, both from different germ cells). Capable of recapitulating some specific function of the organ (e. g. excretion, filtration, neural activity, contraction) Grouped together and spatially organized similar to an organ. Organoid formation recapitulates both major processes of self-organization during development: cell sorting out and spatially restricted lineage commitment. Currently, the goal is not to transplant stem cells or organs. 3d aggregates of pscs / not organized structures can eventually appear. Should only contain the cells from the germ layer(s) of the organ (maximum 2)
