LIFESCI 2 Lecture Notes - Lecture 4: Secretory Protein, Membrane Protein, Lysosome

• School: UCLA
• Department: Life Sciences
• Course: LIFESCI 2
• Professor: Arnold, A.P., Esdin, J.

Document Summary

Copy of rna in nucleus contains instructions for making protein -> to golgi apparatus & shipped to different destinations. Produced in beta pancreatic cells (lots of secretory vesicles) * secretory protein, protein for lysosomes, membrane protein produced by rough er. * proteins need vesicles to get to golgi apparatus from rough er (not connected!) Vesicle v-snares must bind to complementary target membrane t-snares before membranes can fuse. Primary lysosome (lysosome from golgi aparat. waiting to function) + phagosome -> secondary lysosome (functioning) Sorting enzyme encounter lysosomal enzyme -> add tag -> add protein receptor (m6p receptor) -> travels in vesicle to lysosome-> m6p receptor lets go of lysosomal enzyme -> phosphate removed -> recycled m6p receptor.