CBNS 108 Lecture Notes - Lecture 6: Neural Tube, Bone Morphogenetic Protein 4, Neurulation
27 Feb 2020
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Cbns 108: moving beyond pattern formation and into morphogenesis. How cell movements during gastrulation and neurulation build form. Bmp-4 signals induce ectoderm: high bmp epidermal (skin) ectoderm. However, keep mentioning spemann organizer: how it creates a dorsal-ventral axis, the more you keep these axis, the more you break down the embryo that become better specified. They share these 3 methods of altering form and shape without undergoing cell division: cell shape: Germ-layer cells are held together by adherens junctions. The cells in these tissue layers need to be connected to each other. Cells undergo epithelial-to-mesenchymal transition: when they go into the mesoderm they start to detach from the endoderm. Spemann will go in and break down the patterning of the germ layer: based on the starting positions, you are getting areas of high level bmp antagonization, high level with ectoderm neural tissue.
