BIO SCI E109 Lecture Notes - Lecture 2: Aquaporin, Kilogram, Osmosis
28 Sep 2016
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5. 4 passive transport: diffusion relies on the kinetic energy that is intrinsic to all particles, simple diffusion occurs when a solute moves down it gradient without any help. Rate of simple diffusion is always proportional to the concentration gradient: steeper=higher rate: facilitated diffusion uses a protein to move a solute down its gradient. Channel-mediated facilitated diffusion: gated channel / leak channel(pass slower but continuously) 2 affinity: affinity of binding site for the solute is the same regardless of which side of the membrane. So the net direction of transport is determined by the concentration gradient. Glucose enters many body cells by carrier-mediated facilitated diffusion. 2 binding site faces the outside surface conformational change face. 14 inside glucose dissociate from the transporter enters cytosol isoforms: has. Glut2: in liver and transport epithelia of the kidney an intestine. Glut3: in neurons & high affinity for glucose. Glut4: in adipocytes, muscle cells, and other tissues.
