BIO SCI 97 Lecture Notes - Lecture 22: Ap Site, Herbicide, Mutation Rate
29 Mar 2018
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Document Summary
Induced mutations: caused by exogenous (outside) sources of dna damage, sources of exogenous dna damage, chemicals, natural. In food: man made, nitrogren mustard, benzopyrene, uv radiation, from sun. If t is(cid:374)"t re(cid:373)o(cid:448)ed, it (cid:449)ill pair (cid:449)ith a: nucleotide excision repair, carried out by multi-protein complex, this complex patrols dna and removes bulky adducts from dna, ex. Pyrimidine dimers caused by uv: nearby nucleotides are also excised, resulting single-strand gap is filled in by polymerase, steps, damage recognition, dual incisions, excision, gap filling. Mutation rate: 0. 1-1 mutations per genome per cell division, mutations accumulate, even though the mutation rate is low, they still build up. Iclicker: every time a human cell divides, over 50 new mutations can be found in daughter cells, false, mutations can accumulate over the course of successive cell divisions, true. Incidence: about 0. 1: high frequency of colon and several other cancers, aka hnpcc, defect in mismatch repair.
