BIO SCI 94 Lecture Notes - Lecture 4: Allele Frequency, Heterozygote Advantage, Heterosis

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BIO SCI 94 Full Course Notes
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BIO SCI 94 Full Course Notes
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These are four alternative hypotheses to explain the process behind the pattern of changing allele frequencies. Each of the four has different consequences: in nature, mating may not be random with respect to any particular gene, inbreeding, the mating between relatives, is the most intensively studied form of nonrandom mating. Individuals that inbreed are more likely to share alleles they inherited from their common ancestor. Inbreeding depression is a decline in average fitness that takes place when homozygosity increases and heterozygosity decreases in a population. Inbreeding depression results from two processes: many recessive alleles represent loss-of-function mutations. In heterozygotes, these alleles have little or no effect. It helps to think about this in two steps: This does not change allele frequencies see example below. Step 2) inbreeding increases the frequency of individuals who are homozygous for deleterious recessive alleles. Natural selection will subsequently act on these offspring, and that subsequent selection will cause a change in allele frequencies.

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