BIO SCI 47 Lecture Notes - Lecture 19: Sleep Deprivation, Serotonin Transporter, Cortisol
30 May 2018
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Stress Lecture 19
● Sleep deprivation over activates amygdala, increases activity
○ Hippocampus suffers
● Amygdala fires and goes to cingulate
○ Goes to emotional part of brain
● Cingulate talks to decision making (prefrontal/frontal cortex)
○ Gives weak signal back to cingulate, weak signal back to amygdala
○ Amygdala sends info to hypothalamus
■ Sends activation down spinal cord, sends sympathetic nerves
○ Pituitary is activated, secretes ACTH, activates adrenals, secretes cortisol
● After sleep deprivation, higher levels of cortisol
● Crying is parasympathetic, tears are like hormone release
○ Crying is recovery from stress
● As cortisol levels continually rise, mood worsens
○ Higher risk of depression for high responders
● Twin study to see if experience causes change (PTSD) or predisposed
physiology
○ Smaller hippocampal size to begin with
■ Smaller hippocampus has less of a chance of inhibiting amygdala
firing
● 5-HTT is a serotonin transporter “the depression gene”
○ SSRIs inhibit serotonin recycling
Document Summary
Sleep deprivation over activates amygdala, increases activity. Cingulate talks to decision making (prefrontal/frontal cortex) Gives weak signal back to cingulate, weak signal back to amygdala. Sends activation down spinal cord, sends sympathetic nerves. Pituitary is activated, secretes acth, activates adrenals, secretes cortisol. After sleep deprivation, higher levels of cortisol. Crying is parasympathetic, tears are like hormone release. As cortisol levels continually rise, mood worsens. Higher risk of depression for high responders. Twin study to see if experience causes change (ptsd) or predisposed physiology. Smaller hippocampus has less of a chance of inhibiting amygdala firing. 5-htt is a serotonin transporter the depression gene . Maybe people with depression don"t have enough dopamine, norepinephrine, and serotonin. You can inherit long allele or short allele. Stress, environment, life circumstance also influence depression. Short alleles only need a small input to freak out over something. Collectivist cultures is the good of all over the good of yourself.
