BIO SCI 38 Lecture Notes - Lecture 1: Memory Consolidation, Synaptic Plasticity, Episodic Memory
13 Jan 2020
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Recent discovery of glymphatic system of the brain which clears toxic molecules, like amyloid ab during sleep (xie et al. , science 2013) During wakefulness there is a net increase in synaptic strength. During sleep there is synaptic rescaling, which preserves the relative specific weights of synapses but resets the total synaptic drive back to a baseline. This form of resetting of the brain synapses system allows for new learning and keeps the brain from a state of over excitation. Sleep disruption impairs post-learning memory consolidation q. Neuronal ensembles in hippocampus (ca3 and ca1) show sequential learning related place cell discharge during sleep (e. g. , wilson & Disruption of sharp wave ripples in hippocampus during sws can impair spatial memory consolidation (e. g. , ego-stengel & wilson, hippocampus, The trace reactivation theory suggests that newly formed memories, stored via the hippocampus index, are replayed to the neocortex to allow gradual transfer of information to a hippocampus-dependent form. Trace reactivation theory of systems memory consolidation.
