BIO SCI 38 Lecture Notes - Lecture 33: Basolateral Amygdala, Memory Consolidation, Propranolol
10 Jan 2020
School
Department
Course
Professor
Professor Guzowski
Bio sci department
Bio Sci 38
Mind, Memory, and Brain
Course no. 05040
tues/thurs 1-3:50 pm
Location sspa 1170
Professor’s email: [email protected]du
4 units
Office hours by appointment
Summer Session (5 week) 2018
Notes
● Measuring Changes in Neurotransmitters during Behavior:
○ Fast-Scan Cyclic Voltametry (FSCV)
■ Even though microdialysis proved useful for answering some questions, it
suffered from poor sensitivity and temporal resolution. FSCV is better in
both regards.
■ Carbon fiber probe is implanted in brain region of interest.
■ Probe conducts a specific chemical reaction, such as the oxidation of
dopamine, when current is applied.
■ The probe detects the change in the analyte near the probe.
■ FSCV had high temporal resolution (~100 ms) and sensitivity.
● Memory Modulation Works for Many Types of Memory and is an Endogenous
(Naturally Occurring) Process
○ (A) The injection of norepinephrine into the amygdala following place learning
enhanced the rat’s retention of the platform location, but when propranolol was
injected, retention was impaired.
○ (B) Norepinephrine (NE) injected into the amygdala following inhibitory
avoidance training with a weak shock enhanced retention performance.
Propranolol (Pro) injected into the amygdala following inhibitory avoidance
training with strong shock impaired retention (after Hatfield and McGaugh,
1999).
● Stimulation of the Basolateral Amygdala (BLA) Facilitates Memory Consolidation
Processes Served by Different Brain Regions
○ (A) Injecting the stimulant amphetamine into the amygdala following training on
the place-learning version of the Morris water-escape task improved retention
performance.
○ (B) Injecting the amphetamine following training on the visible-platform task
improved retention performance. (Short latency indicates better retention.) The
hippocampus is thought to be a critical storage site for place learning and the
caudate is thought to be critical for the visible-platform task. (After Packard and
Teather, 1998.)
● The Basolateral Amygdala (BLA) Modulates Memory Consolidation But Is Not Needed
for Memory Retrieval
Document Summary
Even though microdialysis proved useful for answering some questions, it suffered from poor sensitivity and temporal resolution. Carbon fiber probe is implanted in brain region of interest. Probe conducts a specific chemical reaction, such as the oxidation of dopamine, when current is applied. The probe detects the change in the analyte near the probe. Fscv had high temporal resolution (~100 ms) and sensitivity. Memory modulation works for many types of memory and is an endogenous (naturally occurring) process. (a) the injection of norepinephrine into the amygdala following place learning enhanced the rat"s retention of the platform location, but when propranolol was injected, retention was impaired. (b) norepinephrine (ne) injected into the amygdala following inhibitory avoidance training with a weak shock enhanced retention performance. Propranolol (pro) injected into the amygdala following inhibitory avoidance training with strong shock impaired retention (after hatfield and mcgaugh, Stimulation of the basolateral amygdala (bla) facilitates memory consolidation.
