NUTR 200 Lecture Notes - Lecture 17: Alcoholic Drink, Aldehyde Dehydrogenase, Jejunum
Document Summary
List beneits and health risks of alcohol consumpion. 4 or more drinks per 2 hours for women. 5 or more per 2 hours for men. Chronic consumpion of more than 1 drink per day for women. Chronic consumpion of more than 2 for men. Rate of metabolism 7-14 g/hour for 70 kg reference person. Some ethanol is metabolized by the stomach cells: majority of ethanol is metabolized by the liver, no storage, must be oxidized immediately, depends on gender, race, size, food, physical condiion, alcohol content. Pathway used to metabolize low to moderate concentraions of alcohol: occurs in the cytosol of liver and stomach cells. 2 parts = 1) alcohol dehydrogenase (adh), 2) aldehyde dehydrogenase (aldh) Pathway used to metabolize high concentraions of alcohol: occurs in liver cells when adh pathway cannot handle demand. Changes in other metabolic pathways during alcohol metabolism: decreased gluconeogenesis, decreased lipid oxidaion. Promotes tg synthesis: increases fat accumulaion in liver.
