NUTR 200 Lecture Notes - Lecture 21: Lipid Peroxidation, Psychoactive Drug, Standard Drink
14 Jun 2020
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Document Summary
Ethanol (ch3-ch2-oh: energy source, 7 kcal/g, 4-6% total calories, psychoactive drug (genetic predisposition to addiction, toxin (liver disease, 1 standard drink is about 14 grams of alcohol, humans metabolize 7-14 g/hour for 70 kg person. Alcohol metabolism: some ethanol is metabolized by the stomach cells, majority of ethanol is metabolized by the liver, no storage, must be oxidized immediately, unregulated metabolism, decreased gluconeogenesis, decreases lipid oxidation. Increases fat accumulation in the liver: what happens when we over consume, rate of oxidation is fairly stable, excess alcohol released into blood, reflected in bac. Alcohol dehydrogenase pathway: pathway used to metabolize low to moderate concentrations of alcohol, occurs int eh cytosol of liver and stomach cells, yields energy, alcohol > acetaldehyde > acetate. Meos pathway: microsomal ethanol oxidizing system, used to metabolize high concentrations of alcohol, occurs in liver cells when adh pathway cannot handle demand, two routes to make acetaldehyde, only one for acetate.
