BIOC 406 Lecture Notes - Lecture 3: Leaving Group, Acyltransferase, Succinic Acid

• School: UW
• Department: Biochemistry
• Course: BIOC 406
• Professor: Peter Brzovic

Document Summary

Lipid transport mobilization of fatty acids and b-oxidation. How are fatty acids transported from the intestine or liver to other. This occurs primarily in the endoplasmic reticulum, and in golgi, they get packaged into large complexes of lipids and proteins: in the intestine, it synthesizes chylomicrons, and in the liver it synthesizes. Vldls (very-low-density lipoproteins: lipoproteins are then released into circulation, where they can then get picked up by cells that need them. These cells have certain receptors on their surface that can engage these lipoprotein molecules and then liberate the fatty acids transported within them: lipases will help unload these lipoproteins. How are fatty acids incorporated into fats: you have a fatty acid with a carboxylate. Carboxylates aren"t very reactive, so you have to activate them. Acyl-coa synthases (there are a variety of different isomers of these specific for chains of different length) will activate the carboxyl group and form acyl-coa intermediate.