BIO 198 Lecture 2: 9.23.16
19 Jan 2017
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Ta review session: sat 9/243:30 to 5:50 pm in hubbell. The content covered today will be on the exam. trna suppressors. An example of a second site suppressor. 2nd site suppressors of a: find by selecting for the a+ phenotype. Mutation to a residue early in the protein, changing structure and causing it to become non-functional thus, prevents functional translation trna mutation. Mutation in s gene is mutation in the anticodon of the trna. Efficiency determined by how often this binds instead of release factor inserts the right amino acid at that point instead. May be concentration dependent if this is diploid: Phenotype of suppressor is (cid:862)ability to suppress(cid:863) in heterozygote diploid, one copy of s- is enough to suppress this phenotype is dominant! Can only assess that in the presence of the original mutation (a-) We want to know if two genes are on the same or on different chromosomes.
