BIO 479 Lecture Notes - Lecture 6: Tryptophan Hydroxylase, Pineal Gland, Fluvoxamine
2 Feb 2018
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Start out as an amino acid = tryptophan. =6 + 5 carbon rings with 2 n-based (cid:336)amine(cid:337) rings. Ac(cid:2210)ve in platelets (cid:336)clo(cid:2224)ng(cid:337) and blood vessels (cid:336)blood ow(cid:337) Ac(cid:2210)ve in smooth muscle in g. i. tract (cid:336)vomi(cid:2210)ng(cid:337) Does not normally stay long in synapse. Can regulate mood in many brain areas. Low serotonin in some areas can lead to clinical depression. Inhibit serotonin reuptake, which keeps serotonin present at the synapse longer, accentuated serotonin"s e ects. Serotonin can be converted to melatonin by n-acetyltransferase (cid:336)nat(cid:337) Nat produc(cid:2210)on in pulsa(cid:2210)le- making melatonin produc(cid:2210)on pulsa(cid:2210)le. Melatonin is part of biological clock in verts. Melatonin in pulses is a (cid:2210)me-giving cue for the rest of the body. Synchronizes di erent ac(cid:2210)vi(cid:2210)es within the body, and the body wit the external environment. Prehormone or prepropep(cid:2210)de is made in the rough er. Pre signal pep(cid:2210)de a(cid:130)ached to rough er membrane. Prohormone snipped and packaged in vesicles. Pro - in vesicles, snip o inac(cid:2210)ve part.
