MIC 301 Lecture Notes - Lecture 16: Innate Immune System, Adaptive Immune System, Natural Killer Cell

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 301
• Professor: Williams Roger

Document Summary

4: c3 made by liver and needed and if not made susceptible to bacteria, complement targets extracellular pathogens, scid = no t cells and no nk cells, hiv = cd4 t cells destroyed. 6: myeloid stem cell (innate except no nk) Mast cells, macrophages, dendritic cells, eosinophils, neutrophils and basophils: lymphoid stem cell (adaptive except for nk) 8 = innate immunity summary and it works against various non-specific pathogens to keep the infection at the site and prevent spreading. 9 = adaptive immunity and needs time because have to wait for dc to present antigens to them. They can also develop a memory which innate cells cannot. Neutrophil + macrophage = clear extracellular bacteria. Nk = clear virally infected cells and tumor cells (intracellular pathogen: if animal lacks nk cells, all test subjects develop tumors but if they have nk cells, only. 5/100 will develop tumors with same amount of the pathogen: 1st cell to kill virally infected cell.