PMY 302 Lecture Notes - Lecture 37: Mycin, Clarithromycin, Superinfection
20 Dec 2018
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Inhibit either the 50s or the 30s subunit of the bacterial ribosome. Or inhibit enzyme needed for protein synthesis (tetracycline) by chelating. Bacteria can actually efflux of the drug. Chelate (takes the divalent cations away from the enzyme so it cannot. Take it in empty stomach due to food interference. Used when penicillin allergic to treat gram+ Static; bind to ribosome so when bacteria have altered ribosome, Take it in empty stomach due to food dec absorption. Inhibit p450; so be careful with other drug interactions. Tight binding to ribosome and causes misreading to the. Used in staph, strep, fragilis, clostridium tetani. Superinfection when have peptic ulcer and see if it is caused. Inhibit dna gyrase(we don"t have this) and topoisomerase. Mechanism: inhibits by binding to transpeptidase by binding to the side of. Gram + and mrsa (doesn"t penetrate to gram -) of the nam/nag. Poke holes; k+ loss leads to inhibition of synthesis in general.
