PMY 302 Study Guide - Midterm Guide: Edexcel, Clindamycin, Clostridium
3 Jun 2016
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Protein synthesis inhibitors, protein synthesis, bacterial ribosome. Ttc: don"t penetrate mammalian cells can"t get to target site: ttc, use. Other: acne: mechanism: inhibit ribosome static, selectivity: doesn"t penetrate mammalian cells, special feature: chelates divalent cations ca2+, mg2+ Prevent drugs from binding to ribosome: resistance. Superinfection: new infection appear during treatment for a primary infection, staphylococcus aureus enterocolitis, candida albicans vagina, mouth, clostridium difficile pseudomembranous colitis e. In risk: hospitalized> 6days, <6 & >60 yrs old, broad spectrum ab: adme. Administration: oral, interference by food (ca2+, mg2+) Distribution: well distributed to all tissues, stored in bone & liver. Excretion: renal, fecal, enterohepatic: chloramphenicol, features: broad spectrum, oral administration, non-toxic, use: haemophilus influenza (meningitis, adverse effects. Aplastic anemia: drug interaction: inhibits p450, phenobarbital & rifampin, decrease metabolism, mechanism: inhibit ribosome, static, selectivity: doesn"t bind to mammalian ribosome, resistance: acetylation by metabolizing it, cm not effective, macrolides, types. Misreading of genetic code, at high dose increase bacterial cell permeability.
