BIO 201 Lecture Notes - Lecture 14: Juxtacrine Signalling, Signal Transduction, Cell Signaling
25 Mar 2017
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Document Summary
Transmitting info from outside of cell to inside of cell without actually moving signal into cell. Important to respond to inside and outside environment. Signal itself (ligand) is produced and secreted by a sender cell and received by a. Signaling modes defined by distance between sender and recipient. Sender and recipient are the same cell/group of cells. Cell responds to its own secreted signals. Secreted signal binds to receptor on original cell. Very small group of identical cells all secreting same signal and responding to it. Signaling molecule is either secreted by sender cell and is part of ecm or attached to sender cell. Membranes are so close to each other that only adjacent cell receives signal. Disadvantages: adjacent cells only (very short range) Signaling molecules diffuse one or several cell diameters away to nearby recipient cells. Advantage: broader than juxtacrine signaling communicate with more cells; moderately fast. Disadvantage: not as precise as juxtacrine; still fairly short range.
