BSC 431 Lecture Notes - Lecture 39: Sarcoma, Hemagglutinin, Influenzavirus C

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Infects several cell types including t helper cells (cd4+), macrophages, and dendritic cells (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Encode an rna-dependent dna polymerase reverse transcriptase. The dna copy of the viral genome is then integrated into the host chromosome to become a cellular gene (cid:1) Group includes a number of viruses that have been show to cause cancer (oncornaviruses) (cid:1) (cid:1) (cid:1) The 3 subfamilies of human retroviruses are: oncovirinae, associated w/ cancer & neurologic disorders, spumavirinae, do not cause clinical disease in humans, lentivirinae, slow onset of disease, cause neurologic disorders & immunosuppression. Endogenous viruses: retrovirus sequences that are incorporated into the human genome (about 1% of the human genome) (cid:1) (cid:1) (cid:1) Begins w/ binding of the viral glycoproteins (gp120 and gp41) to the. Gp41 promotes fusion of the viral envelope and the cell"s plasma membrane (cid:1) Genome is released into the cytoplasm where reverse transcriptase synthesizes a negative strand dna (cdna) (cid:1)