BSC 300 Lecture Notes - Lecture 24: V(D)J Recombination, Human Leukocyte Antigen, Mhc Restriction

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The major histocompatibility complex (mhc) & antigen presentation. The major histocompatibility complex ( mhc ) encodes many proteins involved in immune response. Are highly polymorphic and responsible for graft acceptance/rejection. Display antigens on cell surface & present them to antigen speci c tcrs t-cell activation. Cytotoxic t-cells then produce cytokines and/or kill viral infected cells. Helper t-cells activate cognate b-cells, stimulating them to mature. Both naive b-cell and t-cells have receptors that allow them to interact with speci c epitopes. Similar mechanism to v(d)j recombination generates epitope speci c receptors on the surface of cytotoxic/helper t-cells. Naive b-cells can directly interact with antigens via their igm receptors. T-cell receptors can only recognize epitopes that are associated with speci c glycoprotein complexes on the surface of antigen presenting cells. The various antigen presenting cells that digest foreign pathogens present portions of proteins from the pathogens associated with transmembrane mhc proteins.

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