CMMB 431 Lecture Notes - Lecture 3: Immunoglobulin M, Immunogen, Complement Membrane Attack Complex

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Adaptive immunity is acquired immunity, it is augmented in response to speci c antigens the system encounters. Memory: immunological memory of the system due to previous exposure to pathogen. Involves activated b cells under production of antibodies. Involves complement and opsonization, antigen destruction (so innate system can recognize things and phagocytose) Involves t cells that can destroy cells and lead to in ammation that recruits more cells to site of infection. Antigen: reacts with antibodies or t cell receptors (tcr), not all of them make great immunogen. Immunogen: capable of creating strong immune response, antigens can be chemically modi ed to become immunogens. Antibodies: produced by differentiated b lymphocytes, these are secreted proteins with speci c region of antibody protein that are able to bind to epitope. Epitope: region of antigen that the antibody is capable of recognizing. Mhc in humans is called hla (human leukocyte antigen) Mhc in mice is called histocompatibility complex or h2.

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