BSC 300 Lecture 25: 25 - Cancer (Pt 1)

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 300
• Professor: John Yoder

Document Summary

1 in 5 people will die from cancer : an agressive, hyperproliferative, malignancy of rogue cells that, via uncontrolled growth and hypermutability, wage an evolutionary arms race against one another and the healthy tissue they infest. Inherited and acquired mutations allow cancerous cells to: Sustain proliferative signaling : either through uncontrolled production of mitogens or uncontrolled activation of their pathways. Evade growth suppressors : often by disabling mutations in the suppressors" receptors or the. Activate invasiveness and metastasis : this allows cancer cells to leave a primary tumor and. Enable replicative immortality : continue to proliferate past the number of generations when pathways they regulate establish secondary tumors normal cells senesce and die. Induce angiogenesis : stimulate growth of blood vessels to supply nutrients/oxygen to the tumor. Resist cell death : inactivate the apoptotic pathway and evade the immune system.