BSC 300 Lecture Notes - Lecture 27: Signal Transduction, Mdm2, Zygosity
24 Apr 2018
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Such cells are capable of leaving their original location-- often through a process of epithelial to mesenchymal transition-- migrating to a new location and establishing secondary tumors: a process called metastasis. It"s where you live and lifestyle choices, rather than where you are from, that are the most important components of cancer risk. In other words, each time a cell divides each gene has about a 1 in a million to a. Reduced dependency on external signals (cid:894)growth factors, ecm co(cid:374)tact, etc (cid:895: 2. In germ cells, this rejuvenates them allowing cells to divide without damage to euchromatin: by activating telomerase, cancer cells become immortalized and avoid quiescence induced by shortened telomeres, 4. Genetic instability leading to increased mutation rate: 5. Invasiveness: lack of adhesion molecules and the need to be anchored: 6. Abnormal metabolism: increased rate of nutrient absorption and metabolism in order to fuel excessive biosynthesis: 7.
