BSC 300 Lecture Notes - Lecture 15: Catenin, Threonine, Scaffold Protein

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 300
• Professor: jenny

Document Summary

Important concepts to remember about phosphoinositide signaling pathways: rtks and cytokine receptors can initiate the ip3/dag signaling pathway by activating phospholipase c , rtks and cytokine receptors can initiate another phosphoinositide pathway by activating pi- Important concepts to remember about signaling pathways controlled by ubiquitinylation and. Kb , which acts to terminate signaling, and genes encoding various inflammatory cytokines. Important concepts to remember about signaling pathways controlled by protein cleavage: Step 1: notch binds to delta on an adjacent cell. Step 2: initiation of delta endocytosis by the signaling cell stretches the notch extracellular domain open for adam 10 cleavage: this process is referred to as regulated intramembrane proteolysis (rip) Step 3: the released notch extracellular domain remains bound to delta and is endocytosed by the signaling cell. Step 4: the four-protein -secretase complex nicastrin subunit binds to the notch stump generated by adam 10.