BIO 211 Lecture Notes - Lecture 32: Macula Densa, Afferent Arterioles, Efferent Arteriole
1 Dec 2020
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Document Summary
Test to see how good kidneys work. Estimates how much blood passes through the glomeruli each minute. Myogenic response intrinsic ability of vascular smooth muscle to respond to pressure changes. Similar to autoregulation in other systemic arterioles. Decrease in arterial bp afferent arteriole relaxes (dilates) and increases blood flow into glomerulus in order to maintain gfr. Tubuloglomerular feedback is a paracrine signaling mechanism through which changes in fluid flow through the loop of henle influence gfr. Glomerulus receives feedback on the status of downstream tubular fluid and adjusts filtration to regulate composition of fluid and stabilize gfr. Three type of cells involved in this process: macula densa cells, juxtaglomerular cells and mesangial cells. Macula densa - patch of slender, closely spaced epithelial cells at end of the nephron loop on the side of the tubules facing the arterioles distal convoluting tubule.
