BIO 115 Lecture Notes - Lecture 31: Adalimumab, Hypersensitivity Pneumonitis, Electronvolt
Document Summary
Basic information about treatment of selected ilds. Pneumoconioses, hypersensitivity pneumonitis, drug- or toxin-induced disease. Termination of exposure (if offending agent identified) Pathophysiology (to the extent it is known) of ipf. Subset of idiopathic interstitial pneumonia, which is a subset of interstitial lung disease. Unknown etiology, but expanded interstitial compartment w/ characteristic findings. More prevalent in old age, men (1. 6:1), smokers, those exposed to pollutants, and those who have chronic microaspiration. Genetic predisposition likely - mutation in surfactant, gel forming mucin, Either inflammation is already gone by presentation or it"s just a result of aberrant healing. Multiple microinjuries continual fibrosis fibroblastic (froblastic) foci (of collagen) Median survival is only 3. 5 years (acute exacerbations) Outline a general diagnostic approach to idiopathic pulmonary fibrosis with regards to history and physical examination. Ipf"s symptoms and findings overlap with many other diseases, so . Exhaustive history and physical exam are key. Need to rule out any/all other causes: drug-related ild, occupational ild, connective tissue ild.
