BIOL 221 Lecture Notes - Lecture 7: Bicarbonate, Red Blood Cell, Hemoglobin
3 Mar 2020
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The chloride shift is the exchange of chloride ions (cl between plasma and rbcs. Bicarbonate is produced in the erythrocytes as previously mentioned. The hydrogen ions formed by the reaction bind to the hemoglobin in the cell. Bicarbonate leaves the cells in exchange for chloride at the tissues. The process is reversed in the lungs wherein bicarbonate enters and is converted back into carbon dioxide that diffuses out of the cell; chloride leaves the cell. Co2 binds to reduced hb more efficiently than to oxyhemoglobin. Think spot: how does this affect carbon dioxide binding. The haldane effect refers to the effect of oxygen binding on the ability to bind carbon dioxide. Carbon dioxide binds more readily to hemoglobin when oxygen is not attached. At normal ventilation, ph remains between 7. 35 and 7. 45 (assuming normal metabolism elsewhere). Therefore, the hydrogen ion concentration decreases and ph increases. Therefore, the hydrogen ion concentration increases and ph decreases.
