BIOL 4376 Lecture Notes - Lecture 49: Prodrug, Fetus, Esomeprazole
28 Jul 2020
School
Department
Course
Professor
Document Summary
Due to that they may contain unacceptable levels of a carcinogenic compound ndma. Individuals should use alternative agents like ppis to relieve their heartburn/indigestion. All paths activate the proton pump for the development of gastric acid. If the pp is inhibited, you block the production of gastric acid. These drugs bind to the activated proton pumps. They"re prodrugs, and they"re only activated by an acidic environment. They irreversibly bind to the proton pump to the sulfhydryl pump. However, they have very long efficacy because of the irreversible inactivation of. Diminish daily acid secretion (basal and stimulated by food intake) by 80-95% Once you"ve eaten, you"ve interfered with the ph and absorption. Cyp2c19 inhibitor: one of the cyps that metabolizes diazepam and phenytoin. Interferes with the metabolism; if you inhibit these 2 gabagonisists, you change the concentration and that could result in severe adverse effects like decreasing the brain activity, leading to unconsciousness.
