BIOL 3051 Lecture Notes - Lecture 13: Proton-Pump Inhibitor, Misoprostol, Histamine H2 Receptor
20 Apr 2020
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The classes of medication to consider for our patient include: H2-receptor antagonists like cimetidine, famotidine (pepcid), nizatidine, or ranitidine (zantac) which act at the h2 receptor of histamines to reduce the production of camp, leading to a lesser activation of the h/k atpase proton pump. Mucosal protective agents like misoprostol (arthrotec, diclofenac/misoprostol. Proton pump inhibitors like dexilant (dexlansoprazole), nexium (esomeprazpole), Generally, ppis are extremely efficacious and usually work best when administered about 1 hour before a meal. Ppis also have an incredibly long duration of action due to their irreversible binding nature. In terms of safety, ppis have very few adverse effects aside from the classical nausea, abdominal pain, flatulence, and diarrhea (due to food not being fully digested due to the lack of acid). Ppis are metabolized by cyp2c19 and cyp3a4 and have rapid first-pass hepatic metabolism requiring some dosing considerations.
