BIOL 4376 Lecture 45: lecture 45
21 Jul 2020
School
Department
Course
Professor
1
○ IV
● Treprostinil
○ IV
● Iloprost
○ Inhaled
● AE
○ Flushing
○ Headache
○ Jaw pain
○ Syncope
Leukotrienes Synthesis and Actions
● High level thinking of eicosanoids are synthesized from one cell, and act on a different
cell.
● Synthesized from cleavage of phospholipids in the membrane, but the enzyme is
lipoxygenase.
● Neutrophil promotes chemotaxis
● Leukotriene LD4 acts on cystLT1 receptors that promote bronchoconstriction and edema
that causes bronchospasms in asthma.
Leukotrienes and their Receptors
NSAIDs
● Cyclooxygenase is the enzyme involved in the biosynthetic pathway of prostanoids
○ COX1 and COX2
■ Nonselective inhibitors: ibuprofen, naproxen, APA
■ COX1: indomethacin, ketoralac
● Relatively more selective for 1 over 2
■ COX2: diclofenac, celecoxib
● Paracetamol (APAP): used in lowering fever
○ Analgesic, antipyretic, anti-inflammatory
● Low dose aspirin to decrease the risk of MI and stroke
○ Aspirin irreversibly inhibits COX1 and platelets: inhibits thromboxane; decrease
platelet aggregation (favorable for someone at risk for MI)
Document Summary
High level thinking of eicosanoids are synthesized from one cell, and act on a different cell. Synthesized from cleavage of phospholipids in the membrane, but the enzyme is lipoxygenase. Leukotriene ld4 acts on cystlt1 receptors that promote bronchoconstriction and edema that causes bronchospasms in asthma. Cyclooxygenase is the enzyme involved in the biosynthetic pathway of prostanoids. Low dose aspirin to decrease the risk of mi and stroke. Aspirin irreversibly inhibits cox1 and platelets: inhibits thromboxane; decrease platelet aggregation (favorable for someone at risk for mi) Greek verb to pant, exhale with open mouth, sharp breath . Can be life threatening if it"s not properly managed. More often than not, you see patients coming into the er with. For some patients, it"s worse at night. Some patients are sensitive to cold air. Warm environment to cold may induce bc. Nose is clamped, they take a deep breath then exhale. Maximum amount of air exhaled in one second.
