MEDI7212 Lecture Notes - Lecture 7: Indigestion, Renal Medulla, Prostaglandin E1
Document Summary
Introduction: analgesic, anti-pyretic, anti-inflammatory (high doses only), anti-platelet (aspirin only, headaches, dental pain, menstrual pain, various msk disorders, arthritis, soft tissue injury, some severe pain (bone cancer, reduce need for opioids for post-operative pain. Ineffective for visceral pain (mi, renal colic, acute abdomen), which require opioid analgesics: mechanism. Induce parturition: cox2 is induced in inflammatory cells in response to il-1b and tnfa & main source producing inflammatory pgs, pain production (sensitize nociceptors to other pain inducers; algesia) Increase body temp via hypothalamus action (pge2: recruit inflammatory cells towards injury body parts (vasodilation, oedema, inflammation, constitutive cox2 in kidney produces prostacyclin for its regulation, actions. H2o2 and lipid peroxide levels to overcome drug actions: types, celecoxib, etoricoxib, lumiracoxib (cox2 selective inhibitors coxibs, use - ra, oa, patient contraindication to nsaids bc of gi disturbance, side effects, no cardioprotection, thus increased mi/ stroke risk.
