BIO 447 Lecture Notes - Lecture 2: Thymus, Co-Stimulation, Clonal Selection

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brownfly906

21 Dec 2017

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B-cells | humoral immunity immunity from serum antibodies from plasma cells. Interleukin -1 (il-1) = macrophages, b cells released to induce inflammation, increase production of prostaglandins: alert signal for immune response. B-cell receptor (bcr) specialized receptor; assists in internalizing antigen. B cells cannot function unless stimulated by cytokines from helper t cells. Produced: bone marrow, migrates into bloodstream and lymph organs (to meet antigens) Clone types: plasma/effector cells antibody factories, mass produced, memory cells - circulate long-term, create immunological memory. Allow for rapid response next time around. Provides defensive mechanism against infected/abnormal cells within body tissues using t lymphocytes. Undergo differentiation and acquire secondary characteristics (thymus: selection process eliminates cells that cannot separate self/non-self (positive/negative selection) lymph nodes. Specificity to a mch ii complex + protein. Specificity to a mch i complex + protein. Antigen-presenting cells (apcs) only (has special pocket receptive only apcs) All cells in body, except erythrocytes: dendritic cells: most effective.

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True / False Questions

01. _____ Antibody is composed of 2identical long heavy chains and 2 identical shorter lightchains.

02. _____ Variable (V) and constant(C) regions are part of both heavy and light chains.

03. _____ Variable regions for heavyand light chains from the same antibody molecule are alwaysidentical.

04. _____ Variable region of lightchains are encoded by the DNA sequences that contain rearranged V,D, and J segments.

05. _____ Fc part of the antibody isnot important, F(abâ)₂ fragment has the same binding andeffector capacity.

06. _____ Fab fragments are generatedby alternative splicing.

07. _____ J chain is used as asurrogate light chain during pre-B cell receptor testing forsuccessful V(D)J rearrangement.

08. _____ Binding of the antigen byantibody is stabilized by disulfide bonds.

09. _____ RAG1/2 are always expressedin B cells at high level, because B cells need RAG1/2 to constantlyrearrange their V regions.

10. _____ âNâ (non template)nucleotides are added by TdT.

11. _____ The 12/23 rule is appliedduring class switching.

12. _____ For B cells, V(D)Jrecombination occurs only in the bone marrow.

13. _____ The process of somatichypermutation helps to improve specificity of the antibody.

14. _____ In late pro-B cells, Vsegment is rearranged with DJ segments.

15. _____ Failure to eliminateself-reactive B cells may lead to serious autoimmune diseases.

16. _____ Mature, naÃ¯ve B cellsexpress IgD and any of the other classes of antibody (IgM, IgG,IgA, or IgE) on their surfaces.

17. _____ B1 cells are present in theperitoneal cavity, pleural spaces and brain.

18. _____ AID (activation inducedcytidine deaminase) is expressed only in B cells and it canintroduce breaks in double stranded DNA.

19. _____ Different classes (isotypes)of antibodies have different effector functions, which aretriggered by special receptors expressed by a variety of cells.

20. _____ Plasma cells are terminallydifferentiated cells that produce large quantities ofantibodies.

21. _____ Repeated exposure to thesame antigen eventually leads to immunological exhaustion and lackof immunity, because there is no room for new plasma cells in thebone marrow.

22. _____ Germinal centers arespecialized sites within the bone marrow where Ig genes ofactivated B cells undergo affinity maturation.

23. _____ B cells can present antigensto T helper cells.

24. _____ Co-stimulatory molecules arerequired for efficient generation of memory B cells.

25. _____ Lymphocytes migrate to thelymphoid tissues in response to chemokines.

26. _____ Class switching duringgerminal center reaction is a random process.

27. _____ T cell independent responsescan generate strong and long lasting B cell memory.

28. _____ Fc receptors that arepresent on many different cell types are crucial for removal of thepathogens.

29. _____ The ideal vaccine should bedesigned to mimic the natural course of infection without causingsymptoms of the disease.

30. _____ The protective immunity canbe generated against any pathogen because there is virtuallyunlimited number of possible V regions, thus any antigen can berecognize by an antibody.

oliverhinoceros960

1. during inflamation fluid will passively diffuse out of blod vessels into the nearby infected tissue. This implies all of the following EXCEPT

a.the osmolarity of the fluid surrounding infected tissues is higher than the plasma b the surrounding tissue will swell with excessive fluids c near by cappilaries have become more pearmeable d B-lymphocyte will differeniate to become plasma cell

2. which of the following best describe the qualities of most antigens?

a macromolecules that are foreign to the host b atomic elements that are not normally present in the human body c macromolecules tah tare produced by the host organism d atomic elements that are harmful or toxic

3. an adbantages to adaptive immunity is

a its memory cell that provide quicker larger and more efficient immune response upon second exposure to an antigen b its need for several cells to be activated over several days on first exposure c the ability for its individul cells to respond to many differnt pathogens d the use of antibodies that cause cells lysis and kill invading cells

4, an advantages of innate immunity is

a its a barrier taht prevent pathogens from entering into the body b the specifcity of its individual cell which specialize in the removal on one type of antigen c the numerous step in the activation of its cell that can prevent autoimmune disease d the use of the antibodies to cause cell lysis and kill invading cell

5. B- lymphocytes are categorized as part of the adaptive branch of the immune sys for all of the following reason but one Which of the following is NOT one part of reason B lyphocytes are considered part of the adaptive immunity?

a they produce memory cell when activated b their receptors will bind to only one antigen c they require costimulation from an activated T helper cell d thet are a first line of defense that can begin killing

6. Over lap in the innate and adaptive immune sys is seen in all of the following examples but one Which of the following examples does NOT illustrate the over lap of innate and adaptive immune resposes ??? a dendritic cell presenting antigen on their MHC II proteins to T helper cells b macrophage becoming activated macrophages in response to cytokines realesed by T helper cells c natural killer cell causing of an abnoraml host cell lacking MHC proteins d Plasma cell that produce large amounts of IgE that will ultimetly allow mast cell to relase histamine

7. Which of the following examples below describe an autoimmune disease? a infection and death of T helper cells bya virus resulting in a loss of adaptive immunity b realse of bacterial endotoxins that block acetylcholine realse result is muscle paralysis c antibody binding to acetylcholine receptors of hte motor end palte resulting in muscle weakness.d uncontrolled cell division resulting in cell surface abnormalities recognized by natural killer cell.

8. Which of he following does NOT describe actions of interferon IFN? a virally infected cell can release interferon which attracts natural killer cell to attack and kill the IFN secreting cell b IFN binds to normal uninfected cell stimulating the activation of genes that produce anti viral proteins c IFN will attract macrophages to the secreting cell to be removed bt phagocytosis d IFN can penetrate the virla capsid and destroy the virus

HI HELP PLEASE I NEED ANSWERS TO ALL QUESTIONS PLEASE THANKS

1. during inflamation fluid will passively diffuse out of blod vessels into the nearby infected tissue. This implies all of the following EXCEPT

2. which of the following best describe the qualities of most antigens?

3. an adbantages to adaptive immunity is

4, an advantages of innate immunity is

6. Over lap in the innate and adaptive immune sys is seen in all of the following examples but one Which of the following examples does NOT illustrate the over lap of innate and adaptive immune resposes ??? adendritic cell presenting antigen on their MHC II proteins to T helper cells b macrophage becoming activated macrophages in response to cytokines realesed by T helper cells c natural killer cell causing of an abnoraml host cell lacking MHC proteins d Plasma cell that produce large amounts of IgE that will ultimetly allow mast cell to relase histamine

BIO 447 Lecture Notes - Lecture 2: Thymus, Co-Stimulation, Clonal Selection

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