BIO 326 Lecture Notes - Lecture 12: H2Afy, Condensin, Acetyl Group
22 Mar 2018
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Lecture 12: chapter 12 continued, chapter 13 (unit 3: 12, 13, & 18) Mutations in the genes encoding nuclear lamina proteins cause different diseases with varied symptoms, including: Multisystemic disorders such as premature aging progeroid syndromes. Hutchinson gilford progeria syndrome, instead of aging occurring naturally, characteristics of old age occur during 5 to 6 years of age. Lamin-a gene, lamna cause dramatically premature aging during the first 10 years of life. Without lamina proteins functioning normally, structure of the nuclear lamina is defective. Debilitating genetic condition in which symptoms appear in muscles. Muscle tissue cannot move the skeleton properly; symptoms begin Structural defects of the nuclear lamina leading to structural defects of the nucleus. Cells can control which genes they express by how tightly packed they wind up the chromatin: Spread diffusely throughout the nucleus; appears lighter in color. Transcriptionally active; contains genes that are being expressed.
