BIO 361 Lecture Notes - Lecture 21: Lymphocyte, John Wiley & Sons, Glycolipid
10 Jul 2016
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Document Summary
Oligosaccharides and polysaccharides are typically found on the surface of proteins, or glycoproteins. The glycosidic carbons of sugars can be attacked to form alcohols or amines. These n- or o-linkages give rise to a whole family of glycoproteins. This is opposed to proteoglycans which are made from nam and nag units. Glycoproteins are big proteins with some degradation by carbohydrates on the surface. The n-linkage one finds between proteins and sugars are always to the amino acid asparagine (asn). Sugars can be attached to the amide end of asn and anywhere on the polypeptides as long as some amino acids are present in the vicinity of the internal asn. This location is recognized as a site for n-glycosidation. The first two sugars that are attached to the asn are nag. Attached to those two are sugars are typically mannoses. A consensus sequence always contains a serine or threonine two amino acids from the asn that was glycosdiated.
