BIO 361 Lecture Notes - Lecture 20: Triskelion, Tegra, Spectrin
10 Jul 2016
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Lecture 20c (review) the negatively charged phospholipids are found in the inner leaflet while positively charged phospholipids are found in the outer leaflet. If you discover using a probe that ps is beginning to appear in the outer leaflet in a cell, it tells you that cell is about to die. Membrane proteins that are integral have a lot of hydrophobic fatty acids, and soluble hydrophobic fatty acids tuck into the interior of membranes. There are many proteins that are not integral membrane proteins that are merely stuck. One such way is to put a tail that is very nonpolar onto it. These are two such alcohols (very hydrophobic at the tail that goes into the bilayer and holds the protein on the surface of the membrane). These hydrophobic tail anchors result in an insertion of these proteins onto the inner cytosolic face of the membrane.
